李慧珍
职称：博士/教授
单位：暨南大学环境与气候学院
电话：
邮箱：lihuizhen@jnu.edu.cn
网站：http://yourlab.com.cn/PicDetail.aspx?ID=71
复合污染水生态风险识别与评估
博士，暨南大学环境学院教授，广东省杰出青年基金获得者。2014年博士毕业于中国科学院广州地球化学研究所，通过“优秀青年人才（副研究员）”项目入职中国科学院广州地球化学研究所，2016年9月加入暨南大学环境学院。2018年1月至2020年1月受国家香江学者计划资助，在香港科技大学开展访问研究，合作导师王文雄教授。主要关注有机污染物的水生毒理和生态风险。目前担任国际环境毒理学主流刊物《Environmental Toxicology and Chemistry》和国内期刊《应用生态学报》编委。近年来主持国家和广东省自然科学基金5项，发表论文90篇（其中第一/通讯作者论文42篇），获批国家发明专利6项。曾获得中国科学院院长特别奖、优秀博士论文奖和涂光炽青年人才奖。
1. 效应导向水生态风险识别方法
2. 新污染物的生物有效性和毒性
3. 新污染物的水生毒理学
《环境问题》
《环境化学》
《环境风险评估》
1. Hu, H.; Ma, P.; Li, H.*; You, J., Determining buffering capacity of polydimethylsiloxane-based passive dosing for hydrophobic organic compounds in large-volume bioassays. Sci Total Environ 2024, 914, 169710.
2. Su, H.; Zhang, Q.; Huang, K.; Wang, W.-X.; Li, H.*; Huang, Z.; Cheng, F.; You, J., Two-compartmental toxicokinetic model predicts interspecies sensitivity variation of imidacloprid to aquatic invertebrates. Environ. Sci. Technol. 2023, 57, (29), 10532-10541
3. Cheng, F.; Huang, J.; Li, H.*; Escher, B. I.; Tong, Y.; König, M.; Wang, D.; Wu, F.; Yu, Z.; Brooks, B. W.; You, J.*, Text mining-based suspect screening for aquatic risk assessment in the big data era: Event-driven taxonomy Links chemical exposures and hazards. Environ. Sci. Technol. Lett. 2023, 10, (11), 1004–1010.
4. Gong, Y.; Xiong, J.*; Tan, B.; Li, H.*; Ma, X.; Yi, H.; Wang, L.; You, J., Occurrence and water-sediment exchange of systemic insecticides and their transformation products in an agriculture-dominated basin. J Hazard Mater 2023, 458, 131851.
5. Li, W.; Hu, H.; Liu, F.; Li, H.*; You, J., Influence of dissolved organic carbon on multi-media distribution and toxicity of fipronil and its transformation products in lotic waterways. J. Environ. Sci. 2023, 130, 52-64.
6. Hu, H.; Li, Y.; Lu, G.; Wang, W. X.; Li, H.*; You, J., Spatiotemporal trends of ultraviolet absorbents in oysters from the Pearl River Estuary, south China during 2015-2020. Environ. Pollut. 2023, 323, 121298.
7. Wang, S.*; Lao, W.; Li, H.*; Guo, L.; You, J., Assessing bioaccumulation potential of sediment associated fipronil degradates in oligochaete Lumbriculus variegatus based on passive sampler measured bioavailable concentration. Sci. Total Environ. 2023, 863, 160514.
8. Wu, S.; Li, H.*; You, J., Identification of cytochrome P450 isozymes involved in enantioselective metabolism of fipronil in fish liver: in vitro metabolic kinetics and molecular modeling. Environ. Toxicol. Chem. 2022, 41, (1), 230-239.
9. Tong, Y.; Zhao, X.; Li, H.*; Pei, Y.; Ma, P.; You, J., Using homing pigeons to monitor atmospheric organic pollutants in a city heavily involving in coal mining industry. Chemosphere 2022, 307, 135679.
10. Pei, Y.; Tong, Y.; Li, H.*; You, J., In-situ biological effects, bioaccumulation, and multi-media distribution of organic contaminants in a shallow lake. J. Hazard. Mater. 2022, 427, 128143.
11. Ma, X.; Xiong, J.; Li, H.*; Brooks, B. W.; You, J., Long-term exposure to neonicotinoid insecticide acetamiprid at environmentally relevant concentrations impairs endocrine functions in zebrafish: Bioaccumulation, feminization, and transgenerational effects. Environ. Sci. Technol. 2022, 56, 12494-12505.
12. Liu, Y.; Li, F.; Li, H.*; Tong, Y.; Li, W.; Xiong, J.; You, J., Bioassay-based identification and removal of target and suspect toxicants in municipal wastewater: Impacts of chemical properties and transformation. J. Hazard. Mater. 2022, 437, 129426.
13. Liu, P.; Zhang, L.; Li, H.*; Wei, Y.; Wu, F.; You, J., Reduced concentrations and toxicity of sediment-associated pesticides from vegetable planting field to surrounding waterways: Impacts of chemical properties and intrinsic toxicity. J. Hazard. Mater. 2022, 436, 129292.
14. Li, W.; Li, H.*; Zhang, D.; Tong, Y.; Li, F.; Cheng, F.; Huang, Z.; You, J., Legacy and emerging per- and polyfluoroalkyl substances behave distinctly in spatial distribution and multimedia partitioning: A case study in the Pearl River, China. Environ. Sci. Technol. 2022, 56, 3492−3502.
15. 黎伟宗; 刘源; 李慧珍*; 游静, 市政污水处理厂出水及受纳水体污染和毒性研究进展. 生态毒理学报 2022, 17, (4), 490-504.
16. Li, H.; Zhang, Q.; Su, H.; You, J.*; Wang, W. X., High tolerance and delayed responses of Daphnia magna to neonicotinoid insecticide imidacloprid: Toxicokinetic and toxicodynamic modeling. Environ. Sci. Technol. 2021, 55, (1), 458-467.
17. Mehler, W. T.; Snihur, K. N.; Zhang, Y.; Li, H.*; Alessi, D. S.; Goss, G. G., A complex bioaccumulation story in flowback and produced water from hydraulic fracturing: the role of organic compounds in inorganic accumulation in Lumbriculus variegatus. J. Hazard. Mater. 2021, 414, 125525.
18. Li, Y.; Lu, G.; Wang, W. X.; Li, H.*; You, J., Temporal and spatial characteristics of PAHs in oysters from the Pearl River Estuary, China during 2015-2020. Sci. Total Environ. 2021, 793, 148495.
19. Zhang, L.; Yang, J.; Li, H.*; You, J.; Chatterjee, N.; Zhang, X.*, Development of the transcriptome for a sediment ecotoxicological model species, Chironomus dilutus. Chemosphere 2020, 244, 125541.
20. Li, H.; Yi, X.; Cheng, F.; Tong, Y.; Mehler, W. T.; You, J.*, Identifying organic toxicants in sediment using effect-directed analysis: A combination of bioaccessibility-based extraction and high-throughput midge toxicity testing. Environ. Sci. Technol. 2019, 53, 996-1003.
21. 李慧珍; 裴媛媛; 游静*, 流域水环境复合污染生态风险评估的研究进展. 科学通报 2019, 64, (33), 3412-3428.
22. Li, H.; Zhang, J.; You, J.*, Diagnosis of complex mixture toxicity in sediments: Application of toxicity identification evaluation (TIE) and effect-directed analysis (EDA). Environ. Pollut. 2018, 237, 944-954.
23. Li, H.; You, J.*; Wang, W.-X.*, Multi-compartmental toxicokinetic modeling of fipronil in tilapia: Accumulation, biotransformation and elimination. J. Hazard. Mater. 2018, 360, 420-427.
24. Ma, P.; Li, H.*; You, J., Full life-cycle toxicity assessment of sediment-bound DDT and its degradation products on Chironomus dilutus. Environ. Toxicol. Chem. 2019, 38, (12), 2698-2707.
25. Zhang, J.; You, J.; Li, H.*; Mehler, W. T.; Zeng, E. Y., Particle-scale understanding of cypermethrin in sediment: Desorption, bioavailability, and bioaccumulation in benthic invertebrate Lumbriculus variegatus. Sci. Total Environ. 2018, 642, (15), 638-645.
26. Zhang, J.; Li, H.*; Zhou, Y.; Dou, L.; Cai, L.; Mo, L.; You, J., Bioavailability and soil-to-crop transfer of heavy metals in farmland soils: A case study in the Pearl River Delta, South China. Environ. Pollut. 2018, 235, 710-719.
27. You, J.; Li, H.*, Improving the accuracy of effect-directed analysis: the role of bioavailability. Environ. Sci. Proc. Imp. 2017, 19, 1484-1498.
28. Cheng, F.; Li, H.*; Qi, H.; Han, Q.; You, J., Contribution of pyrethroids in large urban rivers to sediment toxicity assessed with benthic invertebrates Chironomus dilutus: A case study in South China. Environ. Toxicol. Chem. 2017, 36, (12), 3367-3375.
29. Li, H.; Wang, F.; You, J.*, Bioaccumulation of sediment-bound dichlorodiphenyltrichloroethane and heavy metals in benthic polychaete, Nereis succinea from a typical mariculture zone in South China. Marine Pollut. Bull. 2017, 124, 1040-1047.
30. Li, H.; Cheng, F.; Wei, Y.; Lydy, M. J.; You, J. *, Global occurrence of pyrethroid insecticides in sediment and the associated toxicological effects on benthic invertebrates: An overview. J. Hazard. Mater. 2017, 324, 258-271.
31. Li, H.; Lydy, M. J.; You, J. *, Pyrethroids in indoor air during application of various mosquito repellents: Occurrence, dissipation and potential exposure risk. Chemosphere 2016, 144, 2427-2435.
32. Li, H.; You, J. *, Application of species sensitivity distribution in aquatic probabilistic ecological risk assessment of cypermethrin: A case study in an urban stream in South China. Environ. Toxicol. Chem. 2015, 34, (3), 640-648.
33. Li, H.; Zhang, B.; Wei, Y.; Wang, F.; Lydy, M. J.; You, J. *, Bioaccumulation of highly hydrophobic organohalogen flame retardants from sediments: Application of toxicokinetics and passive sampling techniques. Environ. Sci. Technol. 2014, 48, 6957-6964.
34. Li, H.; Zeng, E. Y.; You, J. *, Mitigating pesticide pollution in China requires law enforcement, farmer training, and technological innovation. Environ. Toxicol. Chem. 2014, 33, (5), 963-971.
35. Li, H.; Wei, Y.; Lydy, M. J.; You, J. *, Inter-compartmental transport of organophosphate and pyrethroid pesticides in South China: Implications for a regional risk assessment. Environ. Pollut. 2014, 190, 19-26.
36. Li, H.; Ma, H.; Lydy, M. J.; You, J. *, Occurrence, seasonal variation and inhalation exposure of atmospheric organophosphate and pyrethroid pesticides in an urban community in South China. Chemosphere 2014, 95, 363-369.
37. Li, H.; Sun, B.; Lydy, M. J.; You, J. *, Sediment-associated pesticides in an urban stream in Guangzhou, China: Implication of a shift in pesticide use patterns. Environ. Toxicol. Chem. 2013, 32, (5), 1040-1047.
38. Li, H.; Sun, B.; Chen, X.; Lydy, M. J.; You, J. *, Addition of contaminant bioavailability and species susceptibility to a sediment toxicity assessment: Application in an urban stream in China. Environ. Pollut. 2013, 178, 135-141.
39. 李慧珍; 游静, 被动采样技术在测定沉积物中有机污染物的生物可利用性和毒性中的研究进展. 色谱 2013, 31, (7), 620-625.
40. Li, H.; Mehler, W. T.; Lydy, M. J.; You, J. *, Occurrence and distribution of sediment-associated insecticides in urban waterways in the Pearl River Delta, China. Chemosphere 2011, 82, 1373-1379.
41. Li, H.; Bai, J.; Li, Y.; Cheng, H.; Zeng, E. Y.; You, J. *, Short-range transport of contaminants released from e-waste recycling site in South China. Journal of Environmental Monitoring 2011, 13, 836-843.
42. Li, H.; Wei, Y.; You, J. *; Lydy, M. J., Analysis of sediment-associated insecticides using ustrasound assisted microwave extraction and gas chromatagraphy-mass spectrometry. Talanta 2010, 83, 171-177.
A. 主持的主要科研项目
1. 2023.1-2026.12，国家自然科学基金面上项目，42277265，沉积物中现用农药在无脊椎动物体内的毒代动力学过程及其对毒性的影响机制，53万，在研
2. 2024.4-2027.3，广州市科技计划科技菁英“领航”项目，SL2024A04J00267，电子垃圾拆解区水环境中关键致毒物识别与原位生物暴露风险评估，30万，在研
3. 2019.10-2023.9，广东省自然科学基金杰出青年项目，2019B151502020，利用效应导向分析识别市政废水受纳水体和沉积物毒性成因，100万，结题
4. 2021.4-2023.3，广州市科技计划项目，202102010098，基于大数据的市政废水毒性识别技术及应用，20万，结题
5. 2017.5-2020.5，广东省自然科学基金面上项目，2017A030313065，基于毒代动力学和毒效学的农药生态风险评价方法及应用，10万，结题
6. 2016.1-2018.12，国家自然科学基金青年基金项目，41503091，粒径分布对沉积物中拟除虫菊酯类农药的生物可利用性和毒性的影响机制，24.9万，结题
7. 2016.1-2018.12，广东省自然科学基金博士启动项目，2015A030310219，广州市城市水环境中常见农药的综合生态风险评价，10万，结题
8. 2014.08-2016.08，中国科学院涂光炽青年人才奖，常用农药的毒性效应谱在城市水环境毒性风险评价中的应用， 50万，结题
9. 2014.11-2016.11，南京大学污染控制与资源化研究国家重点实验室开放基金项目，PCRRF14004，城市水体沉积物中常见农药的季节性分布及其毒性评价，5万，结题
B. 参加的主要科研项目
1. 2020.1-2023.12，国家自然科学基金联合基金项目，U1901220，大湾区河口典型有机污染特征及基于多证据链的生态效应，257万，在研，第一参与人
2. 2017.1-2020.6，科技部重大专项子课题，2017ZX07301005-002，流域水环境复合污染生态风险评估技术体系，240万，结题，第一技术骨干
环境污染与健康团队